VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.
Identifieur interne : 000038 ( Main/Exploration ); précédent : 000037; suivant : 000039VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations.
Auteurs : René H Gerling [Allemagne] ; Dominik Drees ; Aaron Scherzinger ; Cathrin Dierkes [Allemagne] ; Silvia Martin-Almedina [Royaume-Uni] ; Stefan Butz [Allemagne] ; Kristiana Gordon [Royaume-Uni] ; Michael Sch Fers [Allemagne] ; Klaus Hinrichs [Allemagne] ; Pia Ostergaard [Royaume-Uni] ; Dietmar Vestweber [Allemagne] ; Tobias Goerge [Allemagne] ; Sahar Mansour [Royaume-Uni] ; Xiaoyi Jiang ; Peter S. Mortimer [Royaume-Uni] ; Friedemann Kiefer [Allemagne]Source :
- JCI insight [ 2379-3708 ] ; 2017.
Abstract
Lack of investigatory and diagnostic tools has been a major contributing factor to the failure to mechanistically understand lymphedema and other lymphatic disorders in order to develop effective drug and surgical therapies. One difficulty has been understanding the true changes in lymph vessel pathology from standard 2D tissue sections.
DOI: 10.1172/jci.insight.93424
PubMed: 28814672
Affiliations:
- Allemagne, Royaume-Uni
- Angleterre, District de Münster, Grand Londres, Rhénanie-du-Nord-Westphalie
- Londres, Münster
- Université de Londres
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Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Drees, Dominik" sort="Drees, Dominik" uniqKey="Drees D" first="Dominik" last="Drees">Dominik Drees</name><affiliation><nlm:affiliation>Pattern Recognition and Image Analysis Group, Department of Computer Science, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Scherzinger, Aaron" sort="Scherzinger, Aaron" uniqKey="Scherzinger A" first="Aaron" last="Scherzinger">Aaron Scherzinger</name><affiliation><nlm:affiliation>Pattern Recognition and Image Analysis Group, Department of Computer Science, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Dierkes, Cathrin" sort="Dierkes, Cathrin" uniqKey="Dierkes C" first="Cathrin" last="Dierkes">Cathrin Dierkes</name><affiliation wicri:level="3"><nlm:affiliation>Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Martin Almedina, Silvia" sort="Martin Almedina, Silvia" uniqKey="Martin Almedina S" first="Silvia" last="Martin-Almedina">Silvia Martin-Almedina</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom.</nlm:affiliation><country 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nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Gordon, Kristiana" sort="Gordon, Kristiana" uniqKey="Gordon K" first="Kristiana" last="Gordon">Kristiana Gordon</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular and Clinical Sciences Institute, St. George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Sch Fers, Michael" sort="Sch Fers, Michael" uniqKey="Sch Fers M" first="Michael" last="Sch Fers">Michael Sch Fers</name><affiliation wicri:level="3"><nlm:affiliation>European Institute for Molecular Imaging, University of Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>European Institute for Molecular Imaging, University of Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Hinrichs, Klaus" sort="Hinrichs, Klaus" uniqKey="Hinrichs K" first="Klaus" last="Hinrichs">Klaus Hinrichs</name><affiliation wicri:level="3"><nlm:affiliation>Visualization and Computer Graphics Group, Department of Computer Science, University of Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Visualization and Computer Graphics Group, Department of Computer Science, University of Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Ostergaard, Pia" sort="Ostergaard, Pia" uniqKey="Ostergaard P" first="Pia" last="Ostergaard">Pia Ostergaard</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular and Clinical Sciences Institute, St. George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Vestweber, Dietmar" sort="Vestweber, Dietmar" uniqKey="Vestweber D" first="Dietmar" last="Vestweber">Dietmar Vestweber</name><affiliation wicri:level="3"><nlm:affiliation>Department Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Goerge, Tobias" sort="Goerge, Tobias" uniqKey="Goerge T" first="Tobias" last="Goerge">Tobias Goerge</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital of Münster, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital of Münster, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Mansour, Sahar" sort="Mansour, Sahar" uniqKey="Mansour S" first="Sahar" last="Mansour">Sahar Mansour</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular and Clinical Sciences Institute, St. George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Jiang, Xiaoyi" sort="Jiang, Xiaoyi" uniqKey="Jiang X" first="Xiaoyi" last="Jiang">Xiaoyi Jiang</name><affiliation><nlm:affiliation>Pattern Recognition and Image Analysis Group, Department of Computer Science, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Clinical Sciences Institute, St. George's University of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Molecular and Clinical Sciences Institute, St. George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><affiliation wicri:level="3"><nlm:affiliation>Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author></analytic><series><title level="j">JCI insight</title><idno type="eISSN">2379-3708</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lack of investigatory and diagnostic tools has been a major contributing factor to the failure to mechanistically understand lymphedema and other lymphatic disorders in order to develop effective drug and surgical therapies. One difficulty has been understanding the true changes in lymph vessel pathology from standard 2D tissue sections.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>District de Münster</li><li>Grand Londres</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Londres</li><li>Münster</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Drees, Dominik" sort="Drees, Dominik" uniqKey="Drees D" first="Dominik" last="Drees">Dominik Drees</name><name sortKey="Jiang, Xiaoyi" sort="Jiang, Xiaoyi" uniqKey="Jiang X" first="Xiaoyi" last="Jiang">Xiaoyi Jiang</name><name sortKey="Scherzinger, Aaron" sort="Scherzinger, Aaron" uniqKey="Scherzinger A" first="Aaron" last="Scherzinger">Aaron Scherzinger</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="H Gerling, Rene" sort="H Gerling, Rene" uniqKey="H Gerling R" first="René" last="H Gerling">René H Gerling</name></region><name sortKey="Butz, Stefan" sort="Butz, Stefan" uniqKey="Butz S" first="Stefan" last="Butz">Stefan Butz</name><name sortKey="Dierkes, Cathrin" sort="Dierkes, Cathrin" uniqKey="Dierkes C" first="Cathrin" last="Dierkes">Cathrin Dierkes</name><name sortKey="Goerge, Tobias" sort="Goerge, Tobias" uniqKey="Goerge T" first="Tobias" last="Goerge">Tobias Goerge</name><name sortKey="Hinrichs, Klaus" sort="Hinrichs, Klaus" uniqKey="Hinrichs K" first="Klaus" last="Hinrichs">Klaus Hinrichs</name><name sortKey="Kiefer, Friedemann" sort="Kiefer, Friedemann" uniqKey="Kiefer F" first="Friedemann" last="Kiefer">Friedemann Kiefer</name><name sortKey="Sch Fers, Michael" sort="Sch Fers, Michael" uniqKey="Sch Fers M" first="Michael" last="Sch Fers">Michael Sch Fers</name><name sortKey="Vestweber, Dietmar" sort="Vestweber, Dietmar" uniqKey="Vestweber D" first="Dietmar" last="Vestweber">Dietmar Vestweber</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Martin Almedina, Silvia" sort="Martin Almedina, Silvia" uniqKey="Martin Almedina S" first="Silvia" last="Martin-Almedina">Silvia Martin-Almedina</name></region><name sortKey="Gordon, Kristiana" sort="Gordon, Kristiana" uniqKey="Gordon K" first="Kristiana" last="Gordon">Kristiana Gordon</name><name sortKey="Mansour, Sahar" sort="Mansour, Sahar" uniqKey="Mansour S" first="Sahar" last="Mansour">Sahar Mansour</name><name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S" last="Mortimer">Peter S. Mortimer</name><name sortKey="Ostergaard, Pia" sort="Ostergaard, Pia" uniqKey="Ostergaard P" first="Pia" last="Ostergaard">Pia Ostergaard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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